Characterization of native, acetylated and enzymatically modified amura starch (Tacca involucrata) for tablet binding

This research is aimed at producing alternative starch used for tablet binding from amura tuber. The microbiological load and physicochemical properties of native modified starches were determined using plate counting method standard BP. Amylose amylopectin content spectrophotometric method. Binding disintegrant abilities these studied paracetamol as a model drug. Paracetamol tablets formulated by wet granulation NAS, AS, EHS binders. characteristics evaluated results this study indicates that microbial Fungi MS range 1 to 30 colonies forming unit (cfc/g). swelling power solubility the found increase with temperature values are higher AS. Also NAS have crushing strength (4.766 ± 0.152), AS (7.000 0.500), (3.900 0.100) (5.633±1.184) significant different (p<0.05) while friability (0.760 0.068, (1.060 0.121, (0.556 0040) (0.873 0.1007) they (p<0.05). disintegration indicate disintegrate faster than MS. dissolution t50, t70 t90 minutes within 70%-97%. (quantity dissolved in 45 min ≥ 70% BP standard). Key words: = Amura Starch (Tacca involucrate), Enzyme hydrolysed Starch, Acetylate Maize starch, Amylose, Amylopectin, BP= British Pharmacopia.